griseofulvin will lessen the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.butabarbital will lessen the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.diazepam will increase the degree or influence of lonafarnib by influencing he